Until now, we have had too many guidelines for assessment of cardiovascular risk factors. In every guideline, there are major and independent risk factors identified, but they vary so much from one guideline to another. There are also too many methods to calculate a patient’s absolute cardiovascular risk have been used on the world (Framingham risk equations, CVD life expectancy model, Dundee coronary risk disk, PROCAM risk function, British regional heart study risk function etc…). Therefore, it is necessary for World Heart Organization/World Heart Federation must to have a common, universal guideline to assess the cardiovascular risk factors in order to have better application of the guidelines into the real world. It would to confront the plethora of available information, which has been affecting the choice of the practitioner. Guideline would be simple, clear, evident-based, beneficial, updated and applicable into practice routines daily. We need the interventions to improve adherence, which focus on the physician and medical office, the heath deliver system and the patient with the final target is the patients have to get optimal evidence based therapy